I have long thought that GUIDS are unique, well GUID actually stands for Globally Unique Identifier. And SharePoint is one unique product using GUIDS everywhere. There are 2^128 possible GUIDs to choose from, so there should be no need to reuse GUIDs as long as I’m alive methinks.
SharePoint uses GUIDs to uniquely identify Site Collections and Sites, and more, and this is for instance exposed through the ID property of the SPSite and SPWeb objects.